ORKA Company Profile and Key Details

ORKA has shown sold momentum, gaining 8.28% over the past week and 20.92% over the past quarter, though year-to-date performance is up 9.63%. Short-term trend indicators are bearishly aligned (SMA20 2.88%, SMA50 7.38%, SMA200 57.69%). The stock’s 14-day RSI is 56.41 (neutral), while the ATR of 1.96 points to higher daily volatility. The stock remains hovering near 52-week lows, trading -6.05% below its high and over 525.71% above its low. Average 10-day trading volume of 647.35 thousand shares is below the 3-month average of 1.14 million, indicating normal recent market interest.

Oruka Therapeutics, Inc. has 66.21 million shares outstanding. The public float is 56.98 million shares, elevated short interest at 17.71% of float. This equals 8.05 million shares. The short ratio is 6.65 days. Institutional investors hold 96.67% of the float. Insiders own 1.23%. Venrock Healthcare Capital Partners III, L.P. holds 4.15 million shares, Fairmount Funds Management LLC has 1.13 million shares and Klein Lawrence Otto has 925.58 thousand shares. Over the past six months, insider transactions show net selling. They sold 3.63 million shares across 27 transactions.

Oruka Therapeutics, Inc. generated EPS of -$2.42 over the past year. Five-year average earnings growth is 36.88%. Wall Street analysts project EPS growth of 9.89% annually over the next five years. Analyst sentiment is bullish. Analyst rating data shows there are 9 Strong Buy ratings, 27 Buy ratings, 0 Hold ratings, 0 Sell rating and 0 Strong Sell ratings. Price targets range from $160.00 to $40.00. The high target offers 73.2% upside. The low target suggests -56.7% downside. The mean target is $86.86. This offers -5.98% upside. Oruka Therapeutics, Inc. earnings surprise history is frequent misses against expectations. The quarter that ended August 10, 2026, missed forecasts by 7.32%. The prior quarter beat by -7.69%. Over the last six quarters, Apple has recorded several small beats. These include -29.82% in May 14, 2025.

Oruka Therapeutics, Inc. last paid a dividend of 0 per share, Dividend and splits history remains an important factor for investors monitoring long-term returns. A discounted cash flow model estimates fair value at around $0.99. This means the shares are trading above this model’s fair value.

Oruka Therapeutics, Inc. (NASDAQ:ORKA) closed at $92.38 USD, gaining $0.73 (0.80%) from the previous close of $91.65. The stock is currently mid-range between its 52-week high and low $14.67 and $115.52. With a market capitalization of about $5.57 billion, Oruka Therapeutics, Inc. is classified as a mid-cap and shows lower-than-market volatility (beta ~-0.39). Key stats such as the average daily volume over the past year has been around 1.15 million shares, volume is running light vs its 52-week average. Headquartered in Menlo Park, CA, Oruka Therapeutics, Inc. operates in the Healthcare sector and the Biotechnology industry. Led by CEO Lawrence Otto Klein, the company employs approximately 68 people and listed since August 08, 1997. Oruka Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing novel monoclonal antibody therapeutics for psoriasis (PsO), and other inflammatory and immunology (I&I) indications.

Oruka Therapeutics, Inc. trades at a P/E ratio of -37.52, slightly below the S&P 500 average, with a price-to-sales ratio of 0.0 and a price-to-book ratio of 5.23 trading at moderately above to book value. The P/FCF stands at -55.26, also below market averages.

Our AI price prediction model suggests that Oruka Therapeutics, Inc. stock has strong potential for upside but may face short-term weakness followed by gains in the medium and long term. 2-Week Outlook: Projected decline of -14.21%, with price expected at $79.25 by September 25, 2026, within a range of $75.05 to $83.65 3-Month Outlook: Projected rise of 159.39%, reaching $239.62 by December 10, 2026, with a range of $238.54 to $241.13. 1-Year Outlook: Projected gain of 12.12%, with price at $103.58 by September 10, 2027, within a range of $95.73 to $109.84.

Oruka Therapeutics, Inc. (NASDAQ:ORKA) shares are flat 9.63% year-to-date currently trading near 52-week highs band. Short-term momentum has been positive over the last quarter, despite recent volatility. Valuation shows Oruka Therapeutics, Inc. trading at a premium to the broader market with a P/E of -37.52. Analyst sentiment is bullish, with the majority of ratings in Buy territory and a mean price target of $76.40, suggesting -17.3% downside. Our AI forecast model points to short-term weakness (-14.21% over two weeks), a medium-term rise (159.39% over three months), and a longer-term gain (12.12% over one year), with expected trading ranges indicating moderate volatility.